WebComputational Chemistry & Chemoinformatics Technologies: - Pharmacophore modelling - Homology Modelling - QSAR/QSPR - Virtual Screening, incl HTVS - Data Mining - Pipeline Pilot/Knime Targets: - P450s - GSTs - Blood Brain Barrier - Solubility - Phospholipidosis - Toxicity - Ion Channels - PDEs - MMPs - Kinases - Antibacterials - … WebOct 24, 2024 · Until toxicity testing is optimized, it is necessary to consider that there is a potential for human risk whenever there is a positive finding of spermatotoxicity in nonclinical or pre-clinical studies for one or more endpoints. The details of the findings and the level of evidence should be included to help physicians and/or pharmacists inform ...
Drug-Induced Phospholipidosis: Prediction, Detection, and
WebOct 9, 2006 · Phospholipidosis – a defence mechanism of the cell?The biological consequence of phospholipid accumulations in several organs has not been evaluated to … ggb earnings call replay
Amiodarone Hepatotoxicity with Absent Phospholipidosis and ... - Hindawi
Webphospholipidosis seem to be protected from the toxic effects of intratracheal silica (Environ. Health Perspec 102:327-378). Phospholipidosis was generally ameliorated after a drug-free period, but in some cases the changes were not completely reversed at the end of a three month drug-free study period. Phospholipidosis is not unique to posaconazole WebPhospholipidosis Skin and Respiratory Sensitization Endocrine Toxicity Reproductive Toxicity Models of Environmental Toxicity References This website uses cookies We use cookies to enhance your browsing experience and analyze our traffic. WebDrug-induced phospholipidosis (PLDsis) is an excessive accumulation of polar phospholipids in cells or tissues/organs caused by xenobiotics. Numerous drugs and chemicals are capable of inducing the storage disorder in animals and humans; however, despite their diverse pharmacological activities, each of these drugs shares common … christ the servant preschool