WebApr 4, 2024 · Functional TMEM106B is a transmembrane protein involved in an intracellular endolysosomal pathway, through which molecules are transported in endosome structures from the cell’s plasma membrane... WebJun 27, 2006 · A TMEM106B truncated C-terminal fragment (residues 120 through 254) was found to aggregate into stable amyloid fibrils in the brain of patients suffering from diverse genetic and sporadic tauopathies, amyloid-beta amyloidoses, synucleinopathies and TDP-43 proteinopathies. It is currently unclear whether TMEM106B fibrils are associated with a ...
Variation in TMEM106B in chronic traumatic encephalopathy
WebMar 8, 2024 · TMEM106B overexpression enhanced SARS-CoV-2 infection as well as pseudovirus infection, suggesting a role in viral entry. Furthermore, single-cell RNA-sequencing of airway cells from patients... WebMar 9, 2024 · Variants in TMEM106B are associated with increased neuroinflammation in aging [ 4 ], frontotemporal lobar degeneration (FTLD)-TDP [ 5 ], and with AD [ 6, 7] and our prior study suggested a protective role of the TMEM106B variant rs3173615 in CTE [ 8 ]. shootings in baton rouge last night
Variation in TMEM106B in chronic traumatic encephalopathy
WebAmong CTE cases, TMEM106B minor allele was also associated with reduced ante-mortem dementia (OR = 0.40, 95% CI 0.16 0.99, p=0.048), but was not associated with TDP-43 pathology. All case-only m ... WebApr 14, 2024 · TMEM106B is a 274 amino acid type II transmembrane protein (Figure 1 A) that under physiological conditions spans the lysosomal and endosomal membranes of … WebSep 2, 2024 · TMEM106B in health and disease Frontotemporal lobar degeneration (FTLD) is a group of heterogeneous, progressive neurodegenerative disorders representing 10–20% of all dementias with an early disease onset, making FTLD the second most common dementia in people under the age of 65 years [ 48, 72 ]. shootings in boston 2021